Seroquel XR (Seroquel) is an antipsychotic medication used to treat mental health conditions, including schizophrenia, bipolar disorder, and major depressive disorder. It is approved for use in adults 18 years of age and older, and is approved for initial presentation in acute psychiatric hospitals.
Approved for adults 18 years of age and older in the United States in 1997 as an adjunct to lithium or divalproex, Seroquel has also been approved for the treatment of adults with major depressive disorder in adults aged 18 years and older, and acute manic episodes associated with bipolar disorder in adults aged 18 years and older.
Approved for adults aged 18 years and older in the United States in 2002 as an adjunct to lithium or divalproex, Seroquel has also been approved for the treatment of adults with major depressive disorder in adults aged 18 years and older, and acute manic episodes associated with bipolar disorder in adults aged 18 years and older.
Seroquel XR is approved for the treatment of schizophrenia in adults 18 years of age and older in the United States and the European Union (EU) in 2006 as an adjunct to lithium or divalproex, Seroquel has also been approved for the treatment of adults with major depressive disorder in adults aged 18 years and older, and acute manic episodes associated with bipolar disorder in adults aged 18 years and older.
Approved for adults 18 years of age and older in the United States in 1996 as an adjunct to lithium or divalproex, Seroquel has also been approved for the treatment of adults with major depressive disorder in adults aged 18 years and older, and acute manic episodes associated with bipolar disorder in adults aged 18 years and older.
Approved for adults 18 years of age and older in the United States in 2002 as an adjunct to lithium or divalproex, Seroquel has also been approved for the treatment of adults with major depressive disorder in adults aged 18 years and older, and acute manic episodes associated with bipolar disorder in adults aged 18 years and older.
Seroquel XR is approved for the treatment of schizophrenia in adults 18 years of age and older in the United States and the European Union in 2006 as an adjunct to lithium or divalproex, Seroquel has also been approved for the treatment of adults with major depressive disorder in adults aged 18 years and older, and acute manic episodes associated with bipolar disorder in adults aged 18 years and older.
Seroquel (quetiapine) is an atypical antipsychotic medication approved for the treatment of schizophrenia in adults 18 years of age and older in the EU, as an adjunct to lithium or divalproex, Seroquel (quetiapine) (equivalent to quetiapine) is an atypical antipsychotic medication approved for the treatment of major depressive disorder in adults 18 years of age and older in the United States and the European Union in 2006 as an adjunct to lithium or divalproex, Seroquel (quetiapine) (equivalent to quetiapine) is an atypical antipsychotic medication approved for the treatment of schizophrenia in adults 18 years of age and older in the EU in 2006.
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Study design
This was a randomized, double-blind, placebo-controlled trial.
Patients and methods
The patients were randomly assigned to receive either Seroquel (25 mg daily) or Seroquel SR (25 mg daily) for 12 weeks.
Of the 100 participants in the Seroquel arm, the mean age was 56 years and the average BMI was 54.1 kg/m2. The mean number of hospitalizations per year was 6.7. The mean duration of illness was 3.5 years. The primary endpoints were: improvement in the Hamilton Depression Rating Scale (HAM-D) score (≥ 5), global (assessed at week 12) and short-term (assessed at week 24) efficacy and safety, as well as symptom control.
Of the 100 participants in the Seroquel arm, the mean age was 63 years and the average BMI was 42.6 kg/m2. The mean number of hospitalizations per year was 7.8. The mean duration of illness was 4.3 years.
Statistical analysis
A two-tailedttest was used for data analysis.
Funding sources
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
No funding sources had any relevant responsibility for the study.
Results
In the first 12 weeks of treatment with Seroquel, the mean HAM-D score improved by 13% (95% CI 12–21,p=.0021); the mean HAM-A score improved by 3.3% (95% CI 2.4–4.1,=.0358); the mean HAM-B score improved by 6.1% (95% CI 5.8–6.2,=.0408); and the mean HAM-C score improved by 6.8% (95% CI 6.4–6.6,=.0263) as compared to baseline, with the Hamilton Depression Rating Scale score having a significant reduction in improvement at week 12.
The mean duration of illness was 2.5 years. The mean duration of symptom control was 5.5 years. The mean improvement in HAM-D score was 3.3% (95% CI 1.3–6.0,=.0435) at week 12, with the HAM-A score improving by 2.4% (95% CI 1.5–4.4,=.0433) at week 24. The Hamilton Depression Rating Scale score had a significant reduction in improvement at week 12, with the HAM-A score improving by 2.5% (95% CI 1.4–4.2,=.0358) at week 24.
Conclusion
Seroquel is an effective treatment for bipolar disorder in adults with a significant improvement in the HAM-D score and in the HAM-A score at week 12.
Seroquel was studied in 50 adults with bipolar disorder and in 80 patients with major depressive disorder and in a sample of 10 patients with schizophrenia who were taking either quetiapine or a combination of the two.
A total of 446 patients were included in the study. Of the 446 patients, 692 were randomized to receive either Seroquel or Seroquel SR, and the remaining 10 were randomized to receive placebo. The study was stopped after 1 week because of the serious adverse events including hypotension and orthostatic hypotension, which were reported in two patients who received Seroquel, and 2 patients who received Seroquel SR. There was no significant difference in the adverse events between the two groups.
The mean treatment time was 2.5 weeks. The average number of adverse events was 3.8 in the Seroquel group and 3.
Quetiapine, the generic name for the brand-name Seroquel, is a type of antidepressant. Although they are not identical, they differ in that they are both serotonin reuptake inhibitors (Ss).
The mechanism of action of Seroquel for the treatment of depression is similar to that of other antidepressants. In some patients, Ss are used for anxiety and depression and in others for the treatment of insomnia.
The most common side effects of Seroquel include:
Some patients, including patients who take Seroquel, experience:
Other side effects of Seroquel include:
If you experience any of these side effects, or if you have any questions about them, talk to your doctor. They can give you the details of what to expect and how to handle them.
You can also check the effects of Seroquel on other medications.
Learn more about the effects of Seroquel and other medications by reading our page.
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Seroquel is the generic name for the brand-name antipsychotic medication Seroquel.
Seroquel was developed by Eli Lilly & Company from a clinical trial, which included 18 patients with schizophrenia, bipolar disorder, and major depressive disorder. The clinical trial included the treatment of patients with schizophrenia, bipolar disorder, and major depressive disorder. The treatment of patients with schizophrenia was first approved by the Food and Drug Administration in 1999.
Seroquel is available in the following forms:
Atypical antipsychotics: Seroquel is approved for treatment of schizophrenia, acute manic episodes, and maintenance treatment of bipolar disorder.
Antipsychotic medications: Seroquel is approved for treatment of bipolar disorder, maintenance treatment of schizophrenia, and acute manic episodes of bipolar disorder.
Seroquel is not approved for use in treatment of depression.
The generic name for Seroquel comes from its chemical structure. The active ingredient is quetiapine. It is also known as the generic name for the brand-name antipsychotic drug Seroquel.
Seroquel is approved for the treatment of:
The following are the approved uses for Seroquel:
Seroquel is also approved for:
Other uses:
Seroquel is approved to treat:
A condition in which an individual experiences hallucinations or mental health problems or symptoms that interfere with normal function of the body, such as movement, hallucinations, or movement disorders. The condition is also called a movement disorder.
Seroquel works by interacting with certain chemicals in the brain. It is thought to be responsible for helping patients with schizophrenia and bipolar disorder to develop new, better, and more consistent thoughts and behaviors.
The mechanism of action of Seroquel is different from that of other antidepressants. Seroquel works by changing the levels of serotonin and dopamine in the brain, which can help patients with schizophrenia and bipolar disorder to have better control over their symptoms.
Seroquel is also thought to affect the excitation and inhibition of certain neurotransmitters. Seroquel blocks the action of certain chemicals in the brain that cause psychosis.
The prevalence of bipolar disorder in adults is 3.6% (20/24, 3.5%) in the United States. The prevalence of schizoaffective disorder is 0.6% (6/100, 2.5%) in the United States. Schizoaffective disorder is the third most common psychiatric disorder among adults in the United States (Table 1).
There is a lack of clinical evaluation of bipolar disorder and treatment of schizophrenia, and its prevalence remains high even up to the present moment. There are no effective treatments for schizoaffective disorder. However, several clinical trials have been conducted, and the treatment of schizophrenia was found to be efficacious in some cases (Table 2).
In the current study, we examined the efficacy of quetiapine (Seroquel) in the treatment of schizoaffective disorder. The primary objective of this study was to examine the efficacy of quetiapine in the treatment of schizoaffective disorder.
The primary efficacy outcome was the rate of recurrence rate (defined as a clinical improvement on the change in the patient's response to the treatment) in the treatment of patients with schizoaffective disorder. The treatment of schizoaffective disorder was evaluated with the patient's response to the treatment as an adjunct to the treatment of patients with schizophrenia. Secondary efficacy outcomes included patient recurrence rate (defined as a change in the patient's response to the treatment after at least 2 weeks of treatment) and the rate of treatment with the patient's response to the treatment as a adjunctive treatment for schizoaffective disorder.
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